CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
Instituto de Microelectrónica de Barcelona

Welcome to the Biomedical Applications Group (GAB) web!

We are placed at the Barcelona Microelectronics Institute (IMB-CNM, CSIC) and we also belong to the CIBER-BBN. The GAB is a recognized and consolidated group by the Generalitat de Catalunya (SGR2014).

The  group takes advantage of the technological capacities available at the  Clean Room of the IMB-CNM in order to provide novel solutions to different biomedical applications. These solutions are mainly based on impedance sensing at different levels of biological organization, i.e. mollecules, cells and organs. As a consequence, the group works jointly with   different biomedical research groups, from the theoretical analysis to the  final clinical trials.
 

News

Graphene-based implant overcomes technical limitation to record brain activity at extremely low frequencies

The body of knowledge about the human brain is growing exponentially, but questions big and small remain unanswered. Researchers have been using electrode arrays to record the brain’s electrical activity for decades, mapping activity in different brain regions to understand what it looks like when everything is working, and what is happening when it is not. Until now, however, these arrays have only been able to detect activity over a certain frequency threshold. A new technology made in Barcelona overcomes this technical limitation, unlocking the wealth of information found below 0.1 Hz, while at the same time paving the way for future brain-computer interfaces.

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Scientists emulate the human blood–retinal barrier on a microfluidic chip

The device contains living cells and mimics the structure and physiological conditions of the blood–retinal barrier. It can be use for testing molecules in vitro and studying diseases such as diabetic retinopathy. It has been developed by scientists at the Barcelona Microelectronics Institute (IMB-CNM) of the CSIC, the CIBER-BBN centre, and at the UAB; together with scientists at the Diabetes and Metabolism group of the Vall d’Hebron Research Institute (VHIR) and CIBERDEM- Institute of Health Carlos III.

For some years, scientists have been researching in order to find ways of reducing animal testing and accelerating clinical trials. In vitro assays with living cells is an alternative, but it has limitations as the interconnection and interaction between cells cannot be easily reproduced.

To overcome the latest, scientists are developing systems that mimic tissues and organ functions in conditions very close to reality. These types of devices, called “Organ-on-a-chip”, include microenvironments and microarchitectures in order to emulate the living organs and tissues.

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